Adolescent mental health is a recognized national priority and a major societal challenge in Canada. Mental health literacy programs have shown that improving knowledge and reducing stigma can empower young people to recognize problems in themselves and peers and to seek help earlier, which in turn facilitates earlier intervention and better outcomes. However, traditional programs (e.g. school-based workshops) face scalability issues and mixed evidence on sustained behavior change. We need innovative solutions that promote mental well-being, prevent crises, and personalize interventions at scale. We plan to address the challenge through building an evidence-based mental health literacy (MHL) approach integrating recent advances in artificial intelligence (AI) that is proactive, culturally inclusive, and scalable. We will develop and evaluate an interactive digital MHL intervention and promote mental health among adolescents. This intervention will be built on an existing evidence-informed MHL curriculum, designed for teachers to use in the classroom: Elementary Mental Health Literacy Resource (EMHLR) for grades 4-6 students (ages of 9-12). Adolescent participants will be invited to provide their perspectives on how to best apply AI into the current EMHLR modules. As a result, the proposed project expects to create: (a) a library of AI-curated MHL content, (b) a chatbot-based user interface that can simulate supportive conversations about mental health, and (c) a suite of interactive activities to build skills in resilience, coping, and help-seeking. All these activities will be implemented under teachers’ supervision who will receive training from the project team. A cluster-controlled study will compare schools using the AI MHL literacy platform vs. control schools using the standard EMHLR, measuring MHL and mental health outcomes: knowledge with based on the content of the standard EMHLR; stigma with a 12-item validated stigma scale; help-seeking with a 5-item validated scale; wellbeing with the validated 5-item World Health Organization Wellbeing Index (WHO-5); and stress with the validated 14-item Perceived Stress Scale (PSS). If successful, we aim to disseminate the AI-powered MHL intervention at national and international level to address adolescent mental health, particularly underserved adolescents.